Looking to cut through the noise and carry the most important nutrition lessons into 2026? Episode #397 launches Part 1 of our Highlights of 2025 series, bringing together the most impactful conversations from the year across protein, dietary fats, gut health, longevity, and science literacy on The Proof.
“The one word that best captures diet quality is balance.” Dr David Katz
This episode features standout moments from a wide range of world-class experts and past conversations on The Proof, including Dr Matthew Nagra, Dr Rupy Aujla, Drew Harrisberg, Dr Steven Novella, Dr Bill Harris, Dr David Katz, Doug Evans, Dr Suzanne Devkota, Dr Jessica Knurick, and Dr Walter Willett.
Across these highlights, I revisit some of the most debated topics in nutrition and health, where social media narratives often collide with long-term outcome data. From protein quality and leucine thresholds to seed oils, the microbiome, sulforaphane, and public health policy, this episode is designed to help you zoom out, stay grounded in evidence, and avoid being pulled into oversimplified stories.
What we cover:
- Why judging protein foods by leucine per calorie misses the bigger picture
- How mixed meals change the plant vs animal protein debate
- How much protein is actually needed for health, ageing, and longevity
- Why anecdotes feel persuasive but often conflict with population-level evidence
- How intelligent people fall into pseudoscience and narrative traps
- What the evidence really shows on omega-6 fats and seed oils
- How to choose a genuinely high quality extra virgin olive oil
- Butter vs plant oils and what substitution studies show about mortality risk
- What diet quality actually means and how it is measured objectively
- Why balance matters more than single nutrients or ingredients
- Sulforaphane, NRF2, and how sprouts support the body’s own defences
- The microbiome, gut barrier health, and why diversity matters
- What microbiome testing can and cannot tell you right now
- MAHA, public health mistrust, and why misdiagnosing the problem leads to the wrong solutions
- Saturated fat, dietary guidelines, and why going backwards would be a mistake
- Seed oils vs beef tallow and the naturalistic fallacy
Thank you for joining me for Part 1 of Highlights of 2025 on The Proof. I hope this episode helps you hold onto nuance, prioritise outcomes over ideology, and move into the year ahead with clarity and confidence.
- Intro (00:00:00)
- Plant Protein vs Animal Protein: Leucine, Muscle & Diet Quality – Simon Hill (00:01:16)
- Is the Protein Debate Really Over? Muscle, Health & Sustainability Explained – Dr Matthew Nagra (00:11:10)
- How Much Protein Do You Actually Need for Aging, Gut Health & Longevity? – Dr Rupy Aujla (00:23:45)
- Why Health Anecdotes Spread Faster Than Science (And Why It Matters) – Drew Harrisberg (00:36:14)
- Why Smart People Fall for Pseudoscience in Nutrition & Health – Dr Steven Novella (00:52:29)
- Are Seed Oils Actually Harmful? Omega-6 Fats & Inflammation Explained – Dr Bill Harris (00:59:24)
- How to Choose the Healthiest Olive Oil (Quality, Labels & Polyphenols) – Simon Hill (01:07:58)
- Butter vs Plant Oils: What the Evidence Says About Mortality & Heart Health – Dr Matthew Nagra (01:13:33)
- What Does a High-Quality Diet Really Mean for Longevity? – Dr David Katz (01:19:49)
- Sulforaphane, Sprouts & Cellular Protection: How Food Impacts Longevity – Doug Evans (01:38:34)
- How the Gut Microbiome Affects Health (And What You Can Change) – Simon Hill (01:46:38)
- What Actually Defines a “Healthy Gut”? Microbiome Testing Explained – Dr Suzanne Devkota (01:50:00)
- What Is MAHA? Nutrition Science, Misinformation & Public Health – Dr Jessica Knurick (02:02:53)
- Saturated Fat, Dietary Guidelines & Why Policy Still Matters – Dr Walter Willett (02:11:17)
- How to Improve Diet Quality at a Population Level – Dr David Katz (02:13:35)
- Seed Oils vs Beef Tallow: Wellness Claims vs Scientific Evidence – Drew Harrisberg (02:20:50)
- Why the Omega-6 Controversy Refuses to Die – Dr Bill Harris (02:24:52)
Resources and links:
- Dietary intake and biomarkers of linoleic acid and mortality: systematic review and meta-analysis of prospective cohort studies
- Red Blood Cell Omega-6 Fatty Acids and Biomarkers of Inflammation in the Framingham Offspring Study
- Extra Virgin Olive Oil Review
- Tallow
Subscribe and stay connected:
Subscribe to The Proof on YouTube, Apple Podcasts or Spotify to ensure you never miss an episode. And don’t forget to follow me on Instagram and X for more insights and updates.
This episode is brought to you by:
38TERA
Consider 38TERA’s DMN prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
Function Health
Take charge of your health with advanced blood testing and personalised insights. Function Health offers a practical way to track key health markers such as cholesterol, blood sugar, and more. Learn more and join at functionhealth.com/simonhill for a $25 credit toward your membership. Only available to those living in the United States.
IM8
With 92 nutrients, including Vitamin B12, Iodine, Selenium and Vitamin D, in highly absorbable forms, IM8 Daily Essentials is the perfect all-in-one daily multi-vitamin to ensure you meet your daily micronutrient needs. IM8 is offering an exclusive 10% off your first order with a free welcome kit when you enter the promo code SIMON at checkout on im8health.com
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
